Duloxetine-d3 (hydrochloride), 1MG

$194.00

Category:

Duloxetine-d3 (hydrochloride), 1MG

Item No. 25229

Technical Information

Formal Name
N-(methyl-d3)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, monohydrochloride
CAS Number
1188266-11-6
Synonyms
  • LY248686-d3
Molecular Formula
C18H16D3NOS • HCl
Formula Weight
336.9
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility
  • Water: 5 mg/ml
SMILES
[2H]C([2H])([2H])NCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChi Code
InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/i1D3;
InChi Key
BFFSMCNJSOPUAY-NIIDSAIPSA-N
Shipping & Storage Information

Storage
4°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
Product Description

Duloxetine-d3 is intended for use as an internal standard for the quantification of duloxetine (Item No. 14317) by GC- or LC-MS. (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).1 It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively).2 It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg.3 Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.

WARNING This product is not for human or veterinary use.

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